ABSTRACT: The importance and efficacy of natural and traditional plants cannot be over-emphasized. The concentration of these phytochemicals varied from plants to plants hence the combination of one or more of the plants in treatment of different ailments in traditional medicine. Qualitative and quantitative analysis of phytochemical constituents of some five Nigerian plants leaves were carried out using aqueous extract of the plant leaves. The following constituents were analysed using standard methods: alkaloids, glycosides, flavonoids, phenol, saponin and anthraquinone. Their level of presence and concentrations were determined using standard methods. The concentrations of alkaloids ranged between Alkaloid: 0.366±0.00-2.163±0.01 (mg/g), Glycosides: 0.223±0.02 - 1.543±0.01 (mg/g), Phenol: 0.367±0.02 - 1.707±0.01 (mg/g), Saponin: 0.747±0.01 - 1.891±0.00 (mg/g), Flavonoid: 0.918±0.01 - 4.237±0.00 (mg/g) and Anthraquinone: 1.647±0.01 - 1.707±0.01 (mg/g) for the five samples. There is significant difference in the concentrations of alkaloids from the five different plants (p<0.05). There is no significant difference in the saponin content of Gossypium hirsutum and Zingiber officinate but there is significant difference in that of Calotropis procera, Alcalypha wikesina and Justicia calycina. Zingiber officinate is rich is flavonoids, Calotropis procera is rich in alkaloids and saponin. It could be concluded that all the plant leaves possess the bioactive compounds tested for which can be used in treatment of differs ailments when compounded as their concentrations varies from one plant to the other.