The south bank of River Benue usually cultivated both in the wet and dry seasons is characterized by anthropogenic activities such as wastes disposal, burning of animal skin and remains and heavy traffic on the bridge. Run-off water from rains could wash heavy metals amongst other contaminants into the river or leave them as sediments on the farm soils and these could be taken up by the vegetables grown on them. This gave impetus to investigating the concentrations of Cd, Cr, Cu, Ni and Pb in Telfairia occidentalis (fluted pumpkin), Talinium triangulare (water leaf) and Amaranthus hybridus (spinach) cultivated along the south bank of River Benue in Makurdi and their farm soils using atomic absorption spectroscopy. The mean concentrations (mg/kg) of Cd, Cr, Cu, Ni and Pb in T. occidentalis were 0.0043, 0.0268, 0.2501, 0.2047 and 0.1868; T. triangulare: 0.0058, 0.0090, 0.0902, 0.2207 and 0.1641 and A. hybridus: 0.0078, 0.0172, 0.0863, 0.0714 and 0.2441, respectively. The mean concentration of the heavy metals in the farm soils ranged between 0.0146 mg/kg cadmium to 4.4992 mg/kg lead in T. triangulare and A. hybridus farm soils respectively. The concentrations of the metals in the vegetables and farm soils showed strong positive correlations. The soil-plant transfer factors of the heavy metals revealed very high absorption of Ni (2.094) and Cu (2.601) by T. triangulare and A. hybridus, respectively. T. occidentalis recorded high absorption of Ni (0.758) and Pb (0.646). Generally, the concentrations of the heavy metals in the soils and vegetable were below the permissible limits set by European Union, WHO/FAO, and Nigerian Agency for Food and Drug Administration and Control (NAFDAC).