International Journal of Modern Biology and Medicine
ISSN: 2165-0136 (online)Search Article(s) by:
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Current Issue: Vol. 5 No. 1or Keyword in Title:
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Table of Content for Vol. 5 No. 1, 2014

Effect of Fungicide Sivic on Seed germination and Seedling Growth of Oryza sativa L.
Sathees Kannan T. M., M. Rajesh and Kaliyamoorthy Jayakumar
      
 PP. 1 - 4
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ABSTRACT: In the present investigation, an attempt has been made to study the effect of Sivic (a fungicide, tricyclzole 75% W.P.) on seed germination and seedling growth of Oryza sativa L. The seeds showed normal germination in control and 0.01%, and there was gradual decrease observed in germination at 0.05% and 0.1% concentrations of Sivic solution. The complete inhibition of germination and seedling growth were observed in higher concentration of Sivic solutions.


Oral Protein-Drug Delivery Systems Suitable for Systemic Circulation
Ibrahim Sani, Abubakar Abdulhamid, Fatima Bello
      
 PP. 5 - 16
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ABSTRACT: Till recently, injection remains the most common means of administering therapeutic proteins and peptides because of their poor oral bioavailability. Currently, there is a high level of interest in the use of the oral route as a portal for protein drug entry to the systemic circulation. As a site for drug delivery, the oral route offers advantages over the conventional parenteral and other alternative routes of drug administration. It provides high patient compliance, ease of administration, less expensive and ability to terminate delivery when required. The oral route appears to be a potential site for drug delivery to the systemic circulation. However, this site is associated with limitations that restrict its use as a route for the systemic delivery of drugs. The low permeability of the membranes that line the oral route results in a low flux of the drugs. Designing and formulating a polypeptide drug delivery through the gastrointestinal tract has been a persistent challenge because of their unfavourable physicochemical properties, which includes enzymatic breakdown, poor membrane permeability and large molecular size. Various strategies are currently under investigation which enhances drug penetration to improve bioavailability from less than 1% to at least 30-50%. These strategies involve chemical modification of the protein drugs, protease inhibitors, absorption enhancers, formulation vehicles and mucoadhesive polymeric systems. These pharmaceutical approaches which overcome various physiological barriers, help to improve oral bioavailability and ultimately achieve formulation goals for oral protein drug delivery.


Potentials of Streptomyces albidoflavus for the Treatment of Infections by Salmonella Species
A. I. Bagudo, A. A. Aliero, S. S. Manga, N. Lawal
      
 PP. 17 - 23
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ABSTRACT: Salmonella species are well known zoonotic agent and remain an important public health problem worldwide. Cattle have been reported as a source of human infection with Salmonellae through direct contact with livestock and indirect through raw milk, cheese, and hamburger meat traced to dairy farms. The 250 samples comprising of milk and fecal samples were collected from cows and stool samples from humans in contact with cows in Labana farm, Aliero. The samples were pre-enriched in buffered peptone water followed by selective enrichment using selenite-F-broths and subsequent inoculation into Salmonella-Shigella agar. Preliminary identification of isolates was done using different conventional biochemical tests. Subsequent confirmation of isolates was carried out using commercially prepared O and H polyvalent antigens. The 105 dilution of soil samples collected were inoculated on salt starch agar after serial dilution to isolate Streptomyces. Confirmation of Streptomyces isolates was done by Gram staining and other biochemical tests. From the taxonomic features, the isolate is Streptomyces albidoflavus in accordance with morphological and biochemical characters. The result showed that 49.5% of cows and 54.6 % of the human subjects shaded Salmonellae. Antimicrobial activity of Streptomyces bioactive molecule to Salmonellae isolated showed that all of the Salmonella isolates were sensitive to bioactive molecules produced by soil Streptomyces.


Effect of Lachnocladium Spp Fermentation on Nutritive Value of Pretreated Sugarcane Bagasse
A. Olagunju, A. Muhammad, I. A. Aimola, S. A. Abdullahi, M. S. Danhassan
      
 PP. 24 - 32
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ABSTRACT: The effect of Lachnocladium spp solid state fermentation on the nutritive value of pretreated sugarcane bagasse was studied. The sample was pretreated with water and sodium hydroxide, followed by microbial fermentation. Enzyme assay of cellulase, mineral analysis and proximate analysis were conducted, the results reveals high microbial enzyme activity on bagasse pretreated with NaOH, followed by water pretreated and untreated bagasse (0.299 µmol/mL/min, 0.183 µmol/mL/min and 0.058 µmol/mL/min), respectively. The proximate analysis shows a significant (p < 0.05) increase in nutrient content of the fermented sugarcane bagasse when compared with unfermented sugarcane bagasse. Results of mineral analysis also show significant increases (P < 0.05) in mineral content of sugarcane bagasse pretreated with water as compared with NaOH treated and untreated samples. Chemical pretreatment and microbial fermentation have been seen to increase the nutritional quality of sugarcane bagasse, thus with its added nutrient value it’s usage in animal feed production might be useful.


Numerical Studies for Solving a Predictive Microbial Growth Model using a New Iterative Method
M. Bilal Ghori, M. Usman, Syed Tauseef Mohyud-Din
      
 PP. 33 - 39
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ABSTRACT: A very important Baranayi and Roberts model arising in predictive microbiology and is nonlinear in nature is discussed. Mathematical results are obtained by using Geijji and Jafari’s New Iterative Method (NIM) and are subsequently compared with Adomian’s Decomposition Method (ADM) [2]. The proposed technique (NIM) is extremely efficient to tackle the complexity of such logistic type models depicting high order accuracy of numerical results. Numerical results coupled with graphical representations reveal the complete reliability and efficiency of suggested method.