International Journal of Modern Biology and Medicine
ISSN: 2165-0136 (online)Search Article(s) by:
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Table of Content for Vol. 5 No. 2, 2014

Observations on the Vascular Wall Flora of Varanasi City, India
Arvind Singh
      
 PP. 40 - 55
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ABSTRACT: The present study was to assess the vascular wall flora of the Varanasi city, India, located on the bank of sacred Ganges River. A total of 173 plant species were recorded from the walls of Varanasi city, of which 171 species were represented by angiosperms while only two species were represented by the pteridophytes. The angiosperms were represented by 131 genera distributed among 47 families. The Poaceae, Asteraceae and Amaranthaceae were the dominant families of the wall flora of Varanasi city. Analysis of flora with respect to life forms indicated the dominance of therophytes over the other life forms. The vascular wall flora of the city is dominated by the exotic species. Lindenbergia indica, Ficus religiosa, Ficus benghalensis, Ficus infectoria, Pteris vittata and Tridax procumbens were the most common flora visible on the walls of the Varanasi city.


Selection and Evaluation of Biochemical Parameters for Anti-alcohol and Hepatoprotective Effects of Foods and Traditional Medicines
Xian-Qiang Zhang, Dong-Ping Xu, An-Na Li, Yu-Jie Zhang, Fang Wang, Jie Zhen, Sha Li, Hua-Bin Li
      
 PP. 56 - 64
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ABSTRACT: Various alcoholic beverages are widely consumed in the world. Moderate consumption of alcohol has shown some positive health effects, but excessive consumption of alcohol may result in serious health problem. Traditionally, people think that some foods and traditional medicines could relieve drunken symptoms. However, this is lack of scientific evidence. To evaluate anti-alcohol and hepatoprotective effects of natural products, some experimental parameters were selected and evaluated in this study. Six biochemical parameters could be used based on function, sensitivity and stability, including concentrations of ethanol and acetaldehyde in blood, alcohol dehydrogenase and aldehyde dehydrogenase activities of liver/blood, and ferric-reducing antioxidant power and trolox equivalent antioxidant capacity of blood.


Thiazolidin and Thiazan-4-ones: Synthesis, Conformational Analysis, Antimicrobial and Cytotoxic Activity
Habiba Tahira Hussain, Mohammad Osama and Wajid Hussain
      
 PP. 65 - 80
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ABSTRACT: Two novel compounds, [(11-{[2-{(4-Chlorophenyl)-methyl}-4-oxo-1,3-thiazolidin-3-yl]amino}-11-oxoundecyl)sulfanyl] acetic acid (4) and 3-[(11-{[2-{(4-chlorophenyl)-methyl}-4-oxo-1,3-thiazan-3-yl]amino}-11-oxoundecyl)sulfanyl] propanoic acid (6) have been synthesized from 10- undecenoic acid hydrazide (1) via p-chloroacetophenone-10-undecenohydrazone (2) using mercaptoacetic acid in the former and 3-mercaptopropanoic acid in the latter (molar ratio, 1:3 in each case). The adducts, ({11-[(2E)-2-{methyl-(4-Chlorobenzylidene)} hydrazino]-11-oxoundecyl} sulfanyl) acetic acid (3) and 3-({11-[(2E)-2-{methyl-(4-Chlorobenzylidene)} hydrazino]-11-oxoundecyl} sulfanyl) propanoic acid (5) respectively are also obtained with them in major amount. The acid hydrazide (1) is first prepared from commercially available 10-undecenoic acid by treatment with hydrazine hydrate in the presence of methanol in acidic medium and then condensed with p-chloro acetophenone (molar ratio, 1:1) to give (2). The hydrazones (2), (3) and (5) exist in two conformers as synperiplanar and antiperiplanar. The synthesized compounds (2)- (6) are evaluated for in vitro antibacterial and antifungal activity by agar well diffusion method against two ΓÇ£Gram negativeΓÇ¥ (Escherichia coli and Pseudomonas aeruginosa) and two ΓÇ£Gram positiveΓÇ¥ (Staphylococcus aureus and Bacillus subtilis) bacteria and one fungus (Candida albicans) using Chloramphenicol and Fluconazole as the standard antibacterial and antifungal drugs respectively for comparison. All compounds documented the potent antibacterial activity against ΓÇ£Gram negativeΓÇ¥ bacteria, of them compounds (5) and (6) which are higher homologues of (3) and (4) showed enhanced activity. Compounds (2), (4) and (6) displayed some activity against ΓÇ£Gram positiveΓÇ¥ bacterial strains also. The compound (2) only demonstrated antifungal activity.These compounds are also screened for cytotoxic activity in a three cell line panel against three types of human cancers; breast, lung, and CNS but showed no any sign of activity.


Regulation and Functions of Interleukin-6 in the Mammalian Testis
Ren-You Gan
      
 PP. 81 - 90
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ABSTRACT: Interleukin-6 (IL-6) is an inflammatory cytokine with multifunction. It can be produced from a variety of cell types and its signaling can transactivate canonical JAK-STAT and Ras-MAPK signaling pathways through its heterodimer receptors, IL-6R and gp-130. Recent researches find that IL-6 and its receptors are also expressed in mammalian testicular cells, and IL-6 signaling plays important roles in testicular functions, such as spermatogenesis and restructuring of testicular cell junctions. Therefore, this review summarized recent researches about IL-6 in mammalian testes, and highlighted the production, regulation and functions of IL-6 in testicular cells. Understanding of IL-6 signaling in the testis can be helpful for targeting IL-6 signaling to treat IL-6-related reproductive disorders.