International Journal of Modern Biology and Medicine
ISSN: 2165-0136 (online)Search Article(s) by:
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Table of Content for Vol. 8 No. 1, 2017

Investigation on the Production of Carotenoid from Molasses by Phaffia rhodozyma
Fang Liu, Ming-Jun Zhu
      
 PP. 1 - 13
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ABSTRACT: This study investigated the sugarcane molasses as a carbon source and other important conditions for cell growth and carotenoid production of yeast Phaffia rhodozyma. Different molasses concentrations had a significant effect on the growth of Phaffia rhodozyma, and the dry cell weight reached 12.35 g/L, with the initial sugar concentration of 50 g/L. The higher initial sugar concentration was not beneficial to carotenoid accumulation, and 30 g/L of initial sugar concentration was determined as optimum initial sugar concentration for carotenoid accumulation with 10.71 g/L biomass. The effects of nitrogen source, C/N ratios and initial pH on the cell growth and carotenoid accumulation were also investigated, and yeast extract as nitrogen source, carbon to nitrogen ratio of 8, and initial pH of 5 were determined. Furthermore, the volume of medium had a significant effect on cell growth and carotenoid production and the medium volume of 25 mL in Erlenmeyer flasks (250 mL) was optimal with 11.81 g/L dry cell weight, and the production of carotenoid was about 32-fold that of the minimum one. The present study suggests that sugarcane molasses is a suitable carbon source for natural carotenoid production by Phaffia rhodozyma.


The Role of Oxidative Stress and Antioxidants in Space Flight
Ya Li, Xiao Meng, Guo-Yi Tang, Hua-Bin Li
      
 PP. 14 - 23
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ABSTRACT: The environment in space is different with that on earth. It has been found that long-term habitation in space could induce several physiological alterations, one of which is the induction of oxidative stress. Two predominant factors, namely space radiation and microgravity, have crucial impacts on oxidative stress in living organisms, including the overproduction of free radicals and the decreased function of antioxidant defense systems. Hence, we discuss the effects of space radiation, microgravity, and a combination of these two factors on oxidative stress and the related underlying mechanisms in the present paper. Moreover, since the intake of dietary antioxidant supplement may have a beneficial role in the astronauts to reduce the oxidative stress induced by space environment, we summarized the antioxidants that have been tested to be effective in reducing oxidative stress.